P3-413: MRI-DERIVED CORTICAL ATROPHY PATTERNS AS PROBABILISTIC PREDICTORS OF SPECIFIC NEURODEGENERATIVE PATHOLOGIES
نویسندگان
چکیده
منابع مشابه
Pathologies of Axonal Transport in Neurodegenerative Diseases.
Gene products such as organelles, proteins and RNAs are actively transported to synaptic terminals for the remodeling of pre-existing neuronal connections and formation of new ones. Proteins described as molecular motors mediate this transport and utilize specialized cytoskeletal proteins that function as molecular tracks for the motor based transport of cargos. Molecular motors such as kinesin...
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BACKGROUND Cortical atrophy, assessed with magnetic resonance imaging (MRI), is an important outcome measure in multiple sclerosis (MS) studies. However, the underlying histopathology of cortical volume measures is unknown. OBJECTIVE We investigated the histopathological substrate of MRI-measured cortical volume in MS using combined post-mortem imaging and histopathology. METHODS MS brain d...
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mg (normal range 78-280), confirming the diagnosis of GM1 Gangliosidosis. Type 3 GM1 gangliosidosis is characterized by onset around the second decade of life with slowly progressive extrapiramidal signs, such as dystonia and parkinsonism. There is also a high prevalence of gait disturbance and dysarthria. Other symptoms are short stature, bone abnormalities, cognitive impairment, ataxia and ca...
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this thesis attempts to measure learning styles, self efficacy and intrinsic motivation as predictors of iranian ielts reading comprehension. in order to address this issue, a quantitative study was conducted on some randomly selected intact students at ferdowsi university. these two groups were assigned as they were undergraduate (ba=91) and graduate (ma =74) students; they were all aged betwe...
MRI derived brain atrophy measures in Multiple Sclerosis
Purpose: To investigate whether MS atrophy can be assessed by SIENA and SIENAX software using other image types from MS research protocols than T1-weighted images without contrast agent, which are not always available. Method: We selected 46 MS patients with identical MRI protocols at two timepoints. We calculated normalized brain volume (NBV) using SIENAX, and percentage brain volume change (P...
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ژورنال
عنوان ژورنال: Alzheimer's & Dementia
سال: 2019
ISSN: 1552-5260
DOI: 10.1016/j.jalz.2019.06.3447